Experimental polycythemia and hemodilution

MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis

Animal African trypanosomosis is a major threat to the economic development and human health in sub-Saharan Africa. Trypanosoma congolense infections represent the major constraint in livestock production, with anemia as the major pathogenic lethal feature. The mechanisms underlying anemia development are ill defined, which hampers the development of an effective therapy. Here, the contribution...

Hemodilution for cerebral ischemia.

If irreversible cerebral infarction from stroke occurred immediately at the time of arterial occlusion, there would be little hope of intervening therapeutically. However, even though there may be a central "core" of severe ischemia where brain tissue dies after a period of several minutes, in most situations there is a surrounding "ischemic penumbra" where blood flow is reduced enough to resul...

Cardiovascular Response to Hyperoxemia, Hemodilution and Burns A clinical and experimental study

Bak, Zoltan. Cardiovascular Response to Hyperoxemia, Hemodilution and Burns – A clinical and experimental study. Linköping University Medical Dissertations No.1013, Ed: The Dean of Faculty of Health Sciences, Sweden 2007. During the last decades less invasive monitoring and analytical tools have been developed for the evaluation of myocardial mechanics in clinical practice. In critical care, th...

Hemodilution in ischemic stroke.

Hyperoxia in extreme hemodilution.

Intraoperative surgical blood loss is initially replaced by infusion of red cell-free, cristalloidal or colloidal solutions. When normovolemia is maintained the ensuing dilutional anemia is compensated by an increase of cardiac output and of arterial oxygen extraction. In the ideal case, a surgical blood loss can entirely be 'bridged' without transfusion by intraoperative normovolemic hemodilut...